Ψ MEFV - Loxodonta africana
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_2HPWTT | Loxodonta africana | LOF (frameshift, premature stop, ss) | Full | Yes | Sequence Trace Archive |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Timing of Loss | "... we found that several gene-inactivating mutations are shared with the Asian elephant, indicatin g that MEFV was already lost in the ancestor of both elephants." | 10.1093/nargab/lqz012 |
| Phenotypic | "MEFV encodes the protein pyrin that controls innate immunity by regulating inflammasome function and selective autophagy of inflammatory activators (84,85)." | 10.1093/nargab/lqz012 |