Reference Gene
| Gene name | Alias | Species | Exons | Type | Paralogs | EC number | OMIM |
|---|---|---|---|---|---|---|---|
| MEFV MEFV innate immunity regulator, pyrin | FMF , MEF , PAAND , TRIM20 | Homo sapiens | 10 | protein-coding | TRIM55 , TRIM63 , TRIM54 , TRIM35 , BSPRY , TRIM13 , RNF39 , TRIM75 , TRIM61 , TRIM60 , RFPL4B , TRIM58 , TRIM21 , TRIM77 , TRIM17 , TRIM64B , TRIM64 , TRIM64C , TRIM4 , TRIM43 , TRIM43B , TRIM6 , TRIM5 , TRIM49B , TRIM49C , TRIM49 , TRIM51G , TRIM51 , TRIM49D2 , TRIM48 , TRIM34 , TRIM22 , TRIM11 , RFPL2 , RFPL3 , RFPL4A , TRIM68 , TRIM38 , TRIM39 , TRIM62 , TRIM74 , TRIM73 , TRIM50 , TRIM14 , TRIM72 , TRIM69 , TRIM15 , TRIM10 , TRIM26 , TRIM27 , TRIM7 , TRIM40 , TRIML2 , TRIML1 , TRIM41 , TRIM31 , TRIM52 | 608107 |
Summary
This gene encodes a protein, also known as pyrin or marenostrin, that is an important modulator of innate immunity. Mutations in this gene are associated with Mediterranean fever, a hereditary periodic fever syndrome. [provided by RefSeq, Jul 2008]
GeneOntology
Gene Loss events - MEFV (2 results)
| GL_ID | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|
| GL_2HPWTT | Loxodonta africana | Proboscidea | LOF (frameshift, premature stop, ss) | Full | Elephantidae | 10.1093/nargab/lqz012 |
| GL_N1QJ2Y | Elephas maximus indicus | Proboscidea | LOF (frameshift, premature stop, ss) | Full | Elephantidae | 10.1093/nargab/lqz012 |