Ψ KLK8 - Physeter catodon

Reference Gene:
Job_ID:
Curator:
GlossID Species Gene Loss Mechanism Loss Type Lineage Specific Evidence Accession Nr.
GL_0YBEXU Physeter catodon LOF (frameshift, premature stop, ss) Full No Multiple individual SRA XM_055079221.1

Statements

Type Excerpt DOI
Functional "Both KLK7 and KLK8 have been related to skin homeostasis (Kishibe et al. 2007), and some experiments suggest that KLK8 is involved in skin desquamation in mammals (Kuwae et al. 2002)." 10.1093/gbe/evx187
Mutation Description "Likewise, the serine-protease KLK8 appears to be absent in all cetaceans through different mechanisms. In sperm whales, this kallikrein displays a complete open-reading frame, but its catalytic site is mutated to a theoretically inactive protease." 10.1093/gbe/evx187
Methodology & Validation "To further ensure that assembly artifacts are not mistaken for gene losses, we used the Trace Archive Nucleotide BLAST to search inside RNA-Seq sets SRX220358, SRX220357, SRX220356, SRX220355, SRX220354, SRX220353, SRX220352, SRX220351 and SRX220350." 10.1093/gbe/evx187
Phenotypic "A loss of several proteases in cetaceans suggests a trend towards a milder inflammatory response relevant to Peto’s paradox: A theory postulated to explain the lower relative incidence of cancer in large mammals (CaulinandMaley2011)." 10.1093/gbe/evx187

Curator Observations

Authors indicate this gene is also lost in all cetaceans, but do not provide further details. See supplementary material for more details.

Related Glosses

GL_ID Symbol Species Order Gene Loss Mechanism Loss Type Lineage Specific Citation
GL_HCRWZZ KLK8 Physeter catodon Artiodactyla LOF (frameshift, premature stop, ss) Full 10.1093/gbe/evx239