Ψ KRT3 - Mus musculus
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_0LK1DO | Mus musculus | LOF (frameshift, premature stop, ss) | Full | No | Genomic & Synteny maps |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Functional | "The major components of hair are alpha-keratins and keratin-associated proteins (KAPs), each of which is encoded by separate gene families [4,5]. (...)All hair-keratins are expressed in the hair shaft, and a subgroup of them is also expressed in claws and nails [4]. The critical role of hair-keratins in hair biology is revealed by the fact that a variety of epidermal diseases are caused by mutations in single hair-keratin genes [5]." | 10.1186/1471-2164-15-869 |
| Mutation Description | "The K3 and K78 genes were lost in mouse lineage (Figure 1)." | 10.1186/1471-2164-15-869 |
| Methodology & Validation | "In order to characterize the gene repertoire present in the keratin gene clusters in laurasiatherian mammals, we manually annotated keratin genes in the genomes of representative species of all major lineages for which genomic information was available." | 10.1186/1471-2164-15-869 |