Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
PGLYRP1 peptidoglycan recognition protein 1	PGRP , TAG7 , PGRPS , PGLYRP , PGRP-S , TNFSF3L	Homo sapiens	3	protein-coding	PGLYRP2 , PGLYRP3 , PGLYRP4		604963

Summary

Enables peptidoglycan binding activity and peptidoglycan immune receptor activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide; killing of cells of other organism; and response to bacterium. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

GeneOntology

Function (1)

Go ID	Value	Evidence
0030544	enables Hsp70 protein binding	IDA

Component (7)

Go ID	Value	Evidence
0070062	located_in extracellular exosome	HDA
0005576	located_in extracellular region	NAS
0005576	located_in extracellular region	TAS
0005615	is_active_in extracellular space	IDA
0097013	located_in phagocytic vesicle lumen	TAS
0035580	located_in specific granule lumen	TAS
1904724	located_in tertiary granule lumen	TAS

Process (13)

Go ID	Value	Evidence
0061844	involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA
0051701	involved_in biological process involved in interaction with host	IEA
0050830	involved_in defense response to Gram-positive bacterium	IBA
0050830	involved_in defense response to Gram-positive bacterium	IDA
0016045	involved_in detection of bacterium	IBA
0016045	involved_in detection of bacterium	IDA
0045087	involved_in innate immune response	NAS
0031640	involved_in killing of cells of another organism	IDA
0050728	involved_in negative regulation of inflammatory response	IEA
0032827	involved_in negative regulation of natural killer cell differentiation involved in immune response	IEA
0032689	involved_in negative regulation of type II interferon production	IEA
0009253	involved_in peptidoglycan catabolic process	IEA
0007165	involved_in signal transduction	IEA

Gene Loss events - PGLYRP1 (4 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_735PRK	Orcinus orca	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1126/sciadv.aaw6671
GL_EIHU74	Physeter catodon	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1126/sciadv.aaw6671
GL_GSWO1N	Balaenoptera acutorostrata	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1126/sciadv.aaw6671
GL_TKT5PS	Tursiops truncatus	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1126/sciadv.aaw6671