Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
LDHC lactate dehydrogenase C	CT32 , LDH3 , LDHX	Homo sapiens	8	protein-coding	LDHAL6A , LDHAL6B , LDHA , LDHB	1.1.1.27	150150

Summary

Lactate dehydrogenase C catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. LDHC is testis-specific and belongs to the lactate dehydrogenase family. Two transcript variants have been detected which differ in the 5' untranslated region. [provided by RefSeq, Jul 2008]

GeneOntology

Function (1)

Go ID	Value	Evidence
0004459	enables L-lactate dehydrogenase activity	IBA

Component (6)

Go ID	Value	Evidence
0005829	located_in cytosol	TAS
0070062	located_in extracellular exosome	HDA
0005739	is_active_in mitochondrion	IBA
0031514	located_in motile cilium	IEA
0005634	located_in nucleus	HDA
1990204	part_of oxidoreductase complex	NAS

Process (9)

Go ID	Value	Evidence
0006754	involved_in ATP biosynthetic process	IEA
0030317	involved_in flagellated sperm motility	IEA
0019244	involved_in lactate biosynthetic process from pyruvate	IEA
0006089	involved_in lactate metabolic process	IBA
0006089	involved_in lactate metabolic process	NAS
0019516	involved_in lactate oxidation	IEA
0042867	involved_in pyruvate catabolic process	IEA
0006090	involved_in pyruvate metabolic process	IBA
0006090	involved_in pyruvate metabolic process	NAS

Gene Loss events - LDHC (14 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_SFSBQK	Neophocaena asiaeorientalis asiaeorientalis	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Phocoenidae	10.1016/j.cub.2021.05.062
GL_T7QXWC	Ziphius cavirostris	Artiodactyla	LOF (frameshift, premature stop, ss)	Polymorphic	Ziphius	10.1016/j.cub.2021.05.062
GL_U7F4MT	Orcinus orca	Artiodactyla	Exon(s) deletion	Full	Delphinidae	10.1016/j.cub.2021.05.062
GL_ZJTIGU	Phocoena phocoena	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Phocoenidae	10.1016/j.cub.2021.05.062