Reference Gene

Gene name Alias Species Exons Type Paralogs EC number OMIM
DSPP dentin sialophosphoprotein DPP , DSP , DGI1 , DMP3 , DFNA39 Homo sapiens 5 protein-coding 125485

Summary

This gene encodes a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family of proteins. The encoded preproprotein is secreted by odontoblasts and proteolytically processed to generate two principal proteins of the dentin extracellular matrix of the tooth, dentin sialoprotein and dentin phosphoprotein. These two protein products may play distinct but related roles in dentin mineralization. Mutations in this gene are associated with dentinogenesis imperfecta and dentin dysplasia. This gene is present in a gene cluster on chromosome 4. Allelic differences due to repeat polymorphisms have been found for this gene. [provided by RefSeq, Jan 2016]

Gene Loss events - DSPP (13 results)

GL_ID Species Order Gene Loss Mechanism Loss Type Lineage Specific Citation
GL_1OH4TP Balaena mysticetus Artiodactyla LOF (frameshift, premature stop, ss) Full No 10.1016/j.ympev.2022.107463
GL_6MZA9Q Balaenoptera musculus Artiodactyla Exon(s) deletion Full No 10.1016/j.ympev.2022.107463
GL_AX3V2Q Caperea marginata Artiodactyla Exon(s) deletion Full No 10.1016/j.ympev.2022.107463
GL_EX1C4U Balaenoptera edeni Artiodactyla Exon(s) deletion Full No 10.1016/j.ympev.2022.107463
GL_K8YLSC Eubalaena glacialis Artiodactyla LOF (frameshift, premature stop, ss) Full No 10.1016/j.ympev.2022.107463
GL_MB0AZK Balaenoptera bonaerensis Artiodactyla Exon(s) deletion Full No 10.1016/j.ympev.2022.107463
GL_QWO1IP Eubalaena australis Artiodactyla LOF (frameshift, premature stop, ss) Full No 10.1016/j.ympev.2022.107463
GL_R09SJY Balaenoptera physalus Artiodactyla Exon(s) deletion Full No 10.1016/j.ympev.2022.107463
GL_S7GGUU Balaenoptera borealis Artiodactyla Exon(s) deletion Full No 10.1016/j.ympev.2022.107463
GL_U1CG2C Balaenoptera acutorostrata Artiodactyla Exon(s) deletion Full No 10.1016/j.ympev.2022.107463