Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
PGK2 phosphoglycerate kinase 2	PGKB , PGKPS , HEL-S-272 , dJ417L20.2	Homo sapiens	1	protein-coding		2.7.2.3	172270

Summary

This gene is intronless, arose via retrotransposition of the phosphoglycerate kinase 1 gene, and is expressed specifically in the testis. Initially assumed to be a pseudogene, the encoded protein is actually a functional phosphoglycerate kinase that catalyzes the reversible conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate, during the Embden-Meyerhof-Parnas pathway of glycolysis, in the later stages of spermatogenesis.[provided by RefSeq, May 2010]

GeneOntology

Function (1)

Go ID	Value	Evidence
0043531	enables ADP binding	IBA

Component (4)

Go ID	Value	Evidence
0005829	is_active_in cytosol	IBA
0070062	located_in extracellular exosome	HDA
0005634	located_in nucleus	HDA
0035686	is_active_in sperm fibrous sheath	IBA

Process (8)

Go ID	Value	Evidence
0061621	involved_in canonical glycolysis	TAS
0030317	involved_in flagellated sperm motility	IEA
0006094	involved_in gluconeogenesis	IBA
0006094	involved_in gluconeogenesis	TAS
0006096	involved_in glycolytic process	IBA
0006096	involved_in glycolytic process	NAS
0016310	involved_in phosphorylation	ISS
0016310	involved_in phosphorylation	NAS

Gene Loss events - PGK2 (12 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_YIOZXI	Delphinapterus leucas	Artiodactyla	Gene deletion	Full	Monodontidae	10.1016/j.cub.2021.05.062
GL_ZWQZBK	Orcinus orca	Artiodactyla	Gene deletion	Full	Delphinidae	10.1016/j.cub.2021.05.062