Reference Gene

Gene name Alias Species Exons Type Paralogs EC number OMIM
PGK2 phosphoglycerate kinase 2 PGKB , PGKPS , HEL-S-272 , dJ417L20.2 Homo sapiens 1 protein-coding 2.7.2.3 172270

Summary

This gene is intronless, arose via retrotransposition of the phosphoglycerate kinase 1 gene, and is expressed specifically in the testis. Initially assumed to be a pseudogene, the encoded protein is actually a functional phosphoglycerate kinase that catalyzes the reversible conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate, during the Embden-Meyerhof-Parnas pathway of glycolysis, in the later stages of spermatogenesis.[provided by RefSeq, May 2010]

GeneOntology

Gene Loss events - PGK2 (12 results)

GL_ID Species Order Gene Loss Mechanism Loss Type Lineage Specific Citation
GL_2CKLJP Manis pentadactyla Pholidota LOF (frameshift, premature stop, ss) Full Pholidota 10.1016/j.cub.2021.05.062
GL_AKB0SL Tursiops truncatus Artiodactyla Gene deletion Full Delphinidae 10.1016/j.cub.2021.05.062
GL_BPX2ZI Monodon monoceros Artiodactyla Gene deletion Full Monodontidae 10.1016/j.cub.2021.05.062
GL_GS6PBZ Neophocaena asiaeorientalis asiaeorientalis Artiodactyla Gene deletion Full Phocoenidae 10.1016/j.cub.2021.05.062
GL_JZDRFE Heterocephalus glaber Rodentia LOF (frameshift, premature stop, ss) Full Heterocephalus 10.1016/j.cub.2021.05.062
GL_KNCNR5 Lagenorhynchus obliquidens Artiodactyla Gene deletion Full Delphinidae 10.1016/j.cub.2021.05.062
GL_MCO9A2 Lipotes vexillifer Artiodactyla Gene deletion Full Lipotidae 10.1016/j.cub.2021.05.062
GL_ORUQ7X Physeter catodon Artiodactyla Gene deletion Full Physeteridae 10.1016/j.cub.2021.05.062
GL_R7HUUN Globicephala melas Artiodactyla Gene deletion Full Delphinidae 10.1016/j.cub.2021.05.062
GL_VWSYZS Manis javanica Pholidota LOF (frameshift, premature stop, ss) Full Pholidota 10.1016/j.cub.2021.05.062