Reference Gene

Gene name Alias Species Exons Type Paralogs EC number OMIM
ACP4 acid phosphatase 4 ACPT , AI1J Homo sapiens 11 protein-coding ACP2 , ACP3 , PXYLP1 , ACP6 , FRA10AC1 3.1.3.2 606362

Summary

Acid phosphatases are enzymes capable of hydrolyzing orthophosphoric acid esters in an acid medium. This gene is up-regulated by androgens and is down-regulated by estrogens in the prostate cancer cell line. This gene exhibits a lower level of expression in testicular cancer tissues than in normal tissues. The protein encoded by this gene has structural similarity to prostatic and lysosomal acid phosphatases. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Gene Loss events - ACP4 (23 results)

GL_ID Species Order Gene Loss Mechanism Loss Type Lineage Specific Citation
GL_GIA8EP Orycteropus afer Tubulidentata LOF (frameshift, premature stop, ss) Full No 10.1038/s41467-018-03667-1
GL_GP2YO1 Eubalaena japonica Artiodactyla LOF (frameshift, premature stop, ss) Full Mysticeti 10.1016/j.ympev.2022.107463
GL_HYAVYV Eubalaena australis Artiodactyla LOF (frameshift, premature stop, ss) Full Mysticeti 10.1016/j.ympev.2022.107463
GL_ILMPGC Caperea marginata Artiodactyla LOF (frameshift, premature stop, ss) Full Mysticeti 10.1016/j.ympev.2022.107463
GL_L9SR42 Megaptera novaeangliae Artiodactyla LOF (frameshift, premature stop, ss) Full Mysticeti 10.1016/j.ympev.2022.107463
GL_MZJ5KJ Eschrichtius robustus Artiodactyla LOF (frameshift, premature stop, ss) Full Mysticeti 10.1016/j.ympev.2022.107463
GL_RQ7IGR Balaenoptera borealis Artiodactyla LOF (frameshift, premature stop, ss) Full Mysticeti 10.1016/j.ympev.2022.107463
GL_TNXBPJ Balaenoptera physalus Artiodactyla LOF (frameshift, premature stop, ss) Full Mysticeti 10.1016/j.ympev.2022.107463
GL_ULLGHZ Balaenoptera acutorostrata Artiodactyla LOF (frameshift, premature stop, ss) Full Mysticeti 10.1016/j.ympev.2022.107463
GL_VBW3R1 Balaenoptera acutorostrata Artiodactyla LOF (frameshift, premature stop, ss) Full No 10.1038/s41467-018-03667-1