Reference Gene

Gene name Alias Species Exons Type Paralogs EC number OMIM
ACP4 acid phosphatase 4 ACPT , AI1J Homo sapiens 11 protein-coding ACP2 , ACP3 , PXYLP1 , ACP6 , FRA10AC1 3.1.3.2 606362

Summary

Acid phosphatases are enzymes capable of hydrolyzing orthophosphoric acid esters in an acid medium. This gene is up-regulated by androgens and is down-regulated by estrogens in the prostate cancer cell line. This gene exhibits a lower level of expression in testicular cancer tissues than in normal tissues. The protein encoded by this gene has structural similarity to prostatic and lysosomal acid phosphatases. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Gene Loss events - ACP4 (23 results)

GL_ID Species Order Gene Loss Mechanism Loss Type Lineage Specific Citation
GL_2B4F97 Kogia breviceps Artiodactyla Exon(s) deletion Full No 10.1016/j.ympev.2022.107463
GL_5NZ4XG Balaenoptera musculus Artiodactyla LOF (frameshift, premature stop, ss) Full Mysticeti 10.1016/j.ympev.2022.107463
GL_8R0NU9 Kogia sima Artiodactyla Exon(s) deletion Full No 10.1016/j.ympev.2022.107463
GL_AA4NVG Monodon monoceros Artiodactyla LOF (frameshift, premature stop, ss) Full No 10.1016/j.ympev.2022.107463
GL_BLA4FC Mesoplodon bidens Artiodactyla LOF (frameshift, premature stop, ss) Full No 10.1016/j.ympev.2022.107463
GL_CUDDXG Physeter catodon Artiodactyla LOF (frameshift, premature stop, ss) Full No 10.1016/j.ympev.2022.107463
GL_DF6REB Dasypus novemcinctus Cingulata LOF (frameshift, premature stop, ss) Full No 10.1038/s41467-018-03667-1
GL_ECNRRO Balaenoptera bonaerensis Artiodactyla LOF (frameshift, premature stop, ss) Full Mysticeti 10.1016/j.ympev.2022.107463
GL_FMGQTN Balaenoptera edeni Artiodactyla LOF (frameshift, premature stop, ss) Full Mysticeti 10.1016/j.ympev.2022.107463
GL_FSOTXP Manis pentadactyla Pholidota LOF (frameshift, premature stop, ss) Full No 10.1038/s41467-018-03667-1