Reference Gene
| Gene name | Alias | Species | Exons | Type | Paralogs | EC number | OMIM |
|---|---|---|---|---|---|---|---|
| RIPK3 receptor interacting serine/threonine kinase 3 | RIP3 | Homo sapiens | 10 | protein-coding | KSR1 , KSR2 , MAP3K21 , WNK4 , MOS | 2.7.11.1 | 605817 |
Summary
The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008]
Gene Loss events - RIPK3 (26 results)
| GL_ID | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|
| GL_QF2QMS | Oryctolagus cuniculus cuniculus | Lagomorpha | LOF (frameshift, premature stop, ss) | Full | Leporidae | 10.3389/fimmu.2021.747737 |
| GL_SGAZ6V | Trichechus manatus | Sirenia | LOF (frameshift, premature stop, ss) | Full | No | 10.3389/fimmu.2021.747737 |
| GL_TRNQNV | Lepus europaeus | Lagomorpha | LOF (frameshift, premature stop, ss) | Full | Leporidae | 10.3389/fimmu.2021.747737 |
| GL_TZBIEZ | Lepus granatensis | Lagomorpha | LOF (frameshift, premature stop, ss) | Full | Leporidae | 10.3389/fimmu.2021.747737 |
| GL_UKSDZA | Lepus timidus | Lagomorpha | LOF (frameshift, premature stop, ss) | Full | Leporidae | 10.3389/fimmu.2021.747737 |
| GL_VHYAP7 | Phocoena sinus | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.3389/fimmu.2021.747737 |