Ψ RIPK3 - Trichechus manatus
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_SGAZ6V | Trichechus manatus | LOF (frameshift, premature stop, ss) | Full | No | Genomic | XM_023725374.1 |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Mutation Description | "Our studies also revealed that species from Afrotherian families, including the African bush elephant (Loxodonta africana, family Elephantidae) and the Cape golden mole (Chrysochloris asiatica, family Chrysochloridae) presented early stop codons in RIPK3 and MLKL, respectively, while the West Indian manatee (Trichechus manatus, family Trichechidae) present early stop codons in both genes (Supplementary File 5)." | 10.3389/fimmu.2021.747737 |
| Timing of Loss | "(...) indicating that RIPK3 and MLKL were present in early stages of Afrotheria evolution, but must have been lost later in specific lineages, resulting in the existence of alternative modes of necroptosis inactivation." | 10.3389/fimmu.2021.747737 |