Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
UBE2N ubiquitin conjugating enzyme E2 N	UBC13 , UbcH13 , UBCHBEN , HEL-S-71 , UbcH-ben , UBCHBEN; UBC13	Homo sapiens	4	protein-coding	UBE2F , UBE2M , UBE2J1 , UBE2H , UBE2K , UBE2J2 , UBE2V2 , UBE2V1 , UBE2T , UBE2C , UBE2W , UBE2L6 , UBE2L5 , UBE2L3 , UBE2D3 , UBE2D2 , UBE2D1 , UBE2D4 , UBE2E2 , UBE2E3 , UBE2E1 , UBE2Q1 , UBE2Q2 , UBE2QL1 , AKTIP , UBE2NL , UBE2S	2.3.2.23	603679

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. [provided by RefSeq, Jul 2008]

GeneOntology

Function (1)

Go ID	Value	Evidence
0005524	enables ATP binding	IEA

Component (16)

Go ID	Value	Evidence
0031372	part_of UBC13-MMS2 complex	IDA
0031372	part_of UBC13-MMS2 complex	IPI
0005737	is_active_in cytoplasm	IC
0005737	located_in cytoplasm	IDA
0005737	located_in cytoplasm	TAS
0005829	located_in cytosol	IDA
0005829	located_in cytosol	TAS
0070062	located_in extracellular exosome	HDA
0098978	located_in glutamatergic synapse	IEA
0005654	located_in nucleoplasm	TAS
0005634	is_active_in nucleus	IBA
0005634	located_in nucleus	IDA
0098794	located_in postsynapse	IEA
0032991	part_of protein-containing complex	IDA
0031371	part_of ubiquitin conjugating enzyme complex	IDA
0000151	part_of ubiquitin ligase complex	IDA

Process (22)

Go ID	Value	Evidence
0000729	acts_upstream_of DNA double-strand break processing	IMP
0050852	involved_in T cell receptor signaling pathway	IMP
0140374	involved_in antiviral innate immune response	IDA
0000724	acts_upstream_of double-strand break repair via homologous recombination	IMP
1904262	involved_in negative regulation of TORC1 signaling	IDA
0045739	involved_in positive regulation of DNA repair	IMP
0051092	involved_in positive regulation of NF-kappaB transcription factor activity	IMP
0043123	involved_in positive regulation of canonical NF-kappaB signal transduction	IMP
2000781	involved_in positive regulation of double-strand break repair	IDA
1902533	involved_in positive regulation of intracellular signal transduction	IDA
1902523	involved_in positive regulation of protein K63-linked ubiquitination	IDA
0006301	involved_in postreplication repair	IBA
0006301	acts_upstream_of postreplication repair	IMP
0043161	involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA
0070534	involved_in protein K63-linked ubiquitination	IBA
0070534	involved_in protein K63-linked ubiquitination	IDA
0070534	involved_in protein K63-linked ubiquitination	IMP
0006513	involved_in protein monoubiquitination	IMP
0000209	involved_in protein polyubiquitination	IMP
0016567	involved_in protein ubiquitination	TAS
0006282	involved_in regulation of DNA repair	TAS
0140252	involved_in regulation protein catabolic process at postsynapse	IEA

Gene Loss events - UBE2N (1 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_H5MMSK	Physeter catodon	Artiodactyla	Other	Full	No	10.1007/s12041-021-01333-y