Reference Gene
| Gene name | Alias | Species | Exons | Type | Paralogs | EC number | OMIM |
|---|---|---|---|---|---|---|---|
| EYS eyes shut homolog | RP25 , SPAM , EGFL10 , EGFL11 , C6orf178 , C6orf179 , C6orf180 , bA74E24.1 , dJ22I17.2 , bA166P24.2 , bA307F22.3 , dJ1018A4.2 , dJ303F19.1 | Homo sapiens | 46 | protein-coding | NTNG2 , NTNG1 , LAMC2 | 612424 |
Summary
The product of this gene contains multiple epidermal growth factor (EGF)-like and LamG domains. The protein is expressed in the photoreceptor layer of the retina, and the gene is mutated in autosomal recessive retinitis pigmentosa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
GeneOntology
Gene Loss events - EYS (19 results)
| GL_ID | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|
| GL_0KTTJ4 | Chrysochloris asiatica | Afrosoricida | Gene deletion | Full | No | 10.1093/icb/icy004 |
| GL_1H3SG3 | Bos taurus | Artiodactyla | Gene deletion | Full | No | 10.1093/icb/icy004 |
| GL_2SZ4VG | Sorex araneus | Eulipotyphla | Gene deletion | Full | No | 10.1093/icb/icy004 |
| GL_9P8J2P | Condylura cristata | Eulipotyphla | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/icb/icy004 |
| GL_AU9MDD | Rhinolophus sinicus | Chiroptera | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/icb/icy004 |
| GL_F5B7TO | Erinaceus europaeus | Eulipotyphla | Gene deletion | Full | No | 10.1093/icb/icy004 |
| GL_FJLQE1 | Odobenus rosmarus | Carnivora | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/icb/icy004 |
| GL_FRRJML | Hipposideros armiger | Chiroptera | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/icb/icy004 |
| GL_K5AJF8 | Octodon degus | Rodentia | Gene deletion | Full | No | 10.1093/icb/icy004 |
| GL_NPQ2EZ | Leptonychotes weddellii | Carnivora | Gene deletion | Full | No | 10.1093/icb/icy004 |