Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
ARR3 arrestin 3	ARRX , cArr , MYP26	Homo sapiens	17	protein-coding	SAG , ARRB2 , ARRB1		301770

Summary

The protein encoded by this gene is a non-visual arrestin which binds to agonist-activated, phosphorylated G protein-coupled receptors. This binding uncouples the receptor from the heterotrimeric G protein, resulting in termination of the G protein-coupled receptor signaling. The encoded protein also is a part of the centrosome, interacting with gamma-tubulin to help regulate proper centrosome function. [provided by RefSeq, May 2016]

GeneOntology

Function (1)

Go ID	Value	Evidence
0001664	enables G protein-coupled receptor binding	IBA

Component (4)

Go ID	Value	Evidence
0005737	located_in cytoplasm	TAS
0001917	located_in photoreceptor inner segment	IDA
0001750	located_in photoreceptor outer segment	IEA
0045202	located_in synapse	IEA

Process (3)

Go ID	Value	Evidence
0002031	involved_in G protein-coupled receptor internalization	IBA
0007165	involved_in signal transduction	IEA
0007601	involved_in visual perception	IBA

Gene Loss events - ARR3 (13 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_TXDIJM	Manis javanica	Pholidota	Gene deletion	Full	No	10.1093/icb/icy004
GL_XPC3EC	Fukomys damarensis	Rodentia	LOF (frameshift, premature stop, ss)	Full	No	10.1093/icb/icy004
GL_Y4NXUB	Orycteropus afer	Tubulidentata	Gene deletion	Full	No	10.1093/icb/icy004