Reference Gene
| Gene name | Alias | Species | Exons | Type | Paralogs | EC number | OMIM |
|---|---|---|---|---|---|---|---|
| ARR3 arrestin 3 | ARRX , cArr , MYP26 | Homo sapiens | 17 | protein-coding | SAG , ARRB2 , ARRB1 | 301770 |
Summary
The protein encoded by this gene is a non-visual arrestin which binds to agonist-activated, phosphorylated G protein-coupled receptors. This binding uncouples the receptor from the heterotrimeric G protein, resulting in termination of the G protein-coupled receptor signaling. The encoded protein also is a part of the centrosome, interacting with gamma-tubulin to help regulate proper centrosome function. [provided by RefSeq, May 2016]
GeneOntology
Gene Loss events - ARR3 (13 results)
| GL_ID | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|
| GL_16TIEH | Nannospalax galili | Rodentia | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/icb/icy004 |
| GL_2TTORP | Chrysochloris asiatica | Afrosoricida | Gene deletion | Full | No | 10.1093/icb/icy004 |
| GL_BOMBFN | Hipposideros armiger | Chiroptera | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/icb/icy004 |
| GL_DJTEO8 | Sorex araneus | Eulipotyphla | Gene deletion | Full | No | 10.1093/icb/icy004 |
| GL_EDIGYL | Echinops telfairi | Gene deletion | Full | No | 10.1093/icb/icy004 | |
| GL_JURCKT | Rhinolophus sinicus | Chiroptera | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/icb/icy004 |
| GL_KCDCNQ | Condylura cristata | Eulipotyphla | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/icb/icy004 |
| GL_L5YVIZ | Heterocephalus glaber | Rodentia | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/icb/icy004 |
| GL_OLK81N | Dasypus novemcinctus | Cingulata | Gene deletion | Full | No | 10.1093/icb/icy004 |
| GL_PPM2HS | Miniopterus natalensis | Chiroptera | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/icb/icy004 |