Reference Gene
| Gene name | Alias | Species | Exons | Type | Paralogs | EC number | OMIM |
|---|---|---|---|---|---|---|---|
| EDA2R ectodysplasin A2 receptor | XEDAR , EDAA2R , EDA-A2R , TNFRSF27 | Homo sapiens | 10 | N/a | 300276 |
Summary
The protein encoded by this gene is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains cysteine-rich repeats and a single transmembrane domain. This protein binds to the EDA-A2 isoform of ectodysplasin, which plays an important role in maintenance of hair and teeth. Alternatively spliced transcript variants encodes distinct protein isoforms. [provided by RefSeq, Apr 2016]
Gene Loss events - EDA2R (4 results)
| GL_ID | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|
| GL_7FHMIN | Manis pentadactyla | Pholidota | LOF (frameshift, premature stop, ss) | Full | Manis | 10.1007/s00239-023-10118-z |
| GL_IYKZFO | Phataginus tricuspis | Pholidota | LOF (frameshift, premature stop, ss) | Full | No | 10.1007/s00239-023-10118-z |
| GL_J6YAM2 | Manis crassicaudata | Pholidota | LOF (frameshift, premature stop, ss) | Full | Manis | 10.1007/s00239-023-10118-z |
| GL_QSZRSO | Manis javanica | Pholidota | LOF (frameshift, premature stop, ss) | Full | Manis | 10.1007/s00239-023-10118-z |