Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
GJA10 gap junction protein alpha 10	CX62	Homo sapiens	1	protein-coding	GJA5 , GJA5 , GJB4 , GJB4 , GJB5 , GJB5 , GJD3 , GJD3 , GJB7 , GJB7 , GJD2 , GJD2 , GJE1 , GJE1 , GJC1 , GJC1 , GJA8 , GJA8 , GJB6 , GJB6 , GJB2 , GJB2 , GJC3 , GJC3 , GJC2 , GJC2 , GJA4 , GJA4 , GJA3 , GJA3 , GJA1 , GJA1 , GJB1 , GJB1 , GJA10 , GJB3 , GJD4 , GJA10 , GJA10 , GJA5 , GJA5 , GJB4 , GJB4 , GJB5 , GJB5 , GJD3 , GJD3 , GJB7 , GJB7 , GJD2 , GJD2 , GJE1 , GJE1 , GJC1 , GJC1 , GJA8 , GJA8 , GJB6 , GJB6 , GJB2 , GJB2 , GJC3 , GJC3 , GJC2 , GJC2 , GJA4 , GJA4 , GJA3 , GJA3 , GJA1 , GJA1 , GJB1 , GJB1 , GJA9 , GJA9 , GJA9 , GJB3 , GJD4		611924

Summary

Connexins, such as GJA10, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits (Sohl et al., 2003 [PubMed 12881038]).[supplied by OMIM, Mar 2008]

GeneOntology

Function (1)

Go ID	Value	Evidence
0005243	enables gap junction channel activity	IBA

Component (2)

Go ID	Value	Evidence
0005922	part_of connexin complex	IBA
0005886	located_in plasma membrane	TAS

Process (5)

Go ID	Value	Evidence
0007267	involved_in cell-cell signaling	IBA
0050908	involved_in detection of light stimulus involved in visual perception	IEA
0007276	involved_in gamete generation	IEA
0007416	involved_in synapse assembly	IEA
0055085	involved_in transmembrane transport	IEA

Gene Loss events - GJA10 (15 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_2OP2VE	Nannospalax galili	Rodentia	LOF (frameshift, premature stop, ss)	Full	No	10.1093/icb/icy004
GL_4HGBD5	Condylura cristata	Eulipotyphla	LOF (frameshift, premature stop, ss)	Full	No	10.1093/icb/icy004
GL_4NUISN	Dasypus novemcinctus	Cingulata	LOF (frameshift, premature stop, ss)	Full	No	10.1093/icb/icy004
GL_AAO6P6	Miniopterus natalensis	Chiroptera	LOF (frameshift, premature stop, ss)	Full	No	10.1093/icb/icy004
GL_FETBGG	Leptonychotes weddellii	Carnivora	LOF (frameshift, premature stop, ss)	Full	No	10.1093/icb/icy004
GL_G42L7W	Hipposideros armiger	Chiroptera	LOF (frameshift, premature stop, ss)	Full	No	10.1093/icb/icy004
GL_HQENKS	Manis javanica	Pholidota	LOF (frameshift, premature stop, ss)	Full	No	10.1093/icb/icy004
GL_J2R4VP	Otolemur garnettii	Primates	LOF (frameshift, premature stop, ss)	Full	No	10.1093/icb/icy004
GL_JL2LMC	Galeopterus variegatus	Dermoptera	LOF (frameshift, premature stop, ss)	Full	No	10.1093/icb/icy004
GL_OK6OVU	Fukomys damarensis	Rodentia	LOF (frameshift, premature stop, ss)	Full	No	10.1093/icb/icy004