Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
CNGA4 cyclic nucleotide gated channel subunit alpha 4	CNG4 , CNG5 , CNCA2 , CNG-4 , CNGB2 , OCNC2 , OCNCb , OCNCBETA	Homo sapiens	7	protein-coding	CNGB1 , CNGB3 , CNGA1 , CNGA2 , CNGA3		609472

Summary

CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant signals (Munger et al., 2001 [PubMed 11739959]).[supplied by OMIM, Mar 2008]

GeneOntology

Function (1)

Go ID	Value	Evidence
0030552	enables cAMP binding	IEA

Component (5)

Go ID	Value	Evidence
0030660	located_in Golgi-associated vesicle membrane	TAS
0060170	located_in ciliary membrane	TAS
0017071	part_of intracellular cyclic nucleotide activated cation channel complex	IBA
0098804	located_in non-motile cilium membrane	ISS
0005886	is_active_in plasma membrane	IBA

Process (6)

Go ID	Value	Evidence
0070588	involved_in calcium ion transmembrane transport	IEA
0006816	involved_in calcium ion transport	ISS
0098655	involved_in monoatomic cation transmembrane transport	IBA
0006813	involved_in potassium ion transport	ISS
0007608	involved_in sensory perception of smell	IEA
0006814	involved_in sodium ion transport	ISS

Gene Loss events - CNGA4 (3 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_JDSUIU	Orcinus orca	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.ympev.2017.01.020
GL_WDSMVC	Tursiops truncatus	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.ympev.2017.01.020
GL_Z4RCOC	Lipotes vexillifer	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.ympev.2017.01.020