Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
ASMT acetylserotonin O-methyltransferase	ASMTY , HIOMT , HIOMTY	Homo sapiens	9	protein-coding		2.1.1.4	402500

Summary

This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2010]

GeneOntology

Function (1)

Go ID	Value	Evidence
0008171	enables O-methyltransferase activity	TAS

Component (1)

Go ID	Value	Evidence
0005829	located_in cytosol	TAS

Process (7)

Go ID	Value	Evidence
0046219	involved_in indolalkylamine biosynthetic process	TAS
0006629	involved_in lipid metabolic process	IEA
0030187	involved_in melatonin biosynthetic process	IBA
0030187	involved_in melatonin biosynthetic process	IDA
0030187	involved_in melatonin biosynthetic process	IEA
0032259	involved_in methylation	IBA
0006412	involved_in translation	TAS

Gene Loss events - ASMT (12 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_UGO5C9	Neophocaena asiaeorientalis	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.3390/genes10020121
GL_XV3HKC	Lipotes vexillifer	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.3390/genes10020121