Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
TAS2R60 taste 2 receptor member 60	T2R56 , T2R60	Homo sapiens	1	protein-coding	TAS2R16 , TAS2R41 , TAS2R30 , TAS2R36 , TAS2R33 , TAS2R19 , TAS2R20 , TAS2R50 , TAS2R45 , TAS2R43 , TAS2R31 , TAS2R46 , TAS2R10 , TAS2R8 , TAS2R13 , TAS2R14 , TAS2R9 , TAS2R42 , TAS2R7 , TAS2R4 , TAS2R38 , TAS2R3 , TAS2R5 , TAS2R1 , TAS2R40 , TAS2R39		613968

Summary

This gene encodes a member of the bitter taste receptor family which belong to the G protein-coupled receptor superfamily and are predominantly expressed in taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a seven-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered together with eight other taste receptor genes on chromosome 7. [provided by RefSeq, Jul 2017]

GeneOntology

Function (1)

Go ID	Value	Evidence
0004930	enables G protein-coupled receptor activity	NAS

Component (3)

Go ID	Value	Evidence
0016020	is_active_in membrane	IBA
0016020	located_in membrane	IDA
0005886	located_in plasma membrane	TAS

Process (3)

Go ID	Value	Evidence
0007186	involved_in G protein-coupled receptor signaling pathway	IEA
0001580	NOT involved_in detection of chemical stimulus involved in sensory perception of bitter taste	IDA
0050913	involved_in sensory perception of bitter taste	NAS

Gene Loss events - TAS2R60 (13 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_3PIDWQ	Physeter catodon	Artiodactyla	Other	Full	No	10.1016/j.cub.2021.02.057
GL_6FDFYU	Balaenoptera acutorostrata	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1186/s12862-014-0218-8
GL_AY4OPK	Kogia sima	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1186/s12862-014-0218-8
GL_CDLCDH	Tursiops truncatus	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1186/s12862-014-0218-8
GL_CTLA5V	Hippopotamus amphibius	Artiodactyla	LOF (frameshift, premature stop, ss)	Full		10.1186/s12862-014-0218-8
GL_DWKSVO	Lipotes vexillifer	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1186/s12862-014-0218-8
GL_E7DUBP	Delphinus capensis	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1186/s12862-014-0218-8
GL_IFNMH8	Sousa chinensis	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1186/s12862-014-0218-8
GL_KIQXQC	Hippopotamus amphibius	Artiodactyla	Other	Full	No	10.1016/j.cub.2021.02.057
GL_LVKLQW	Orcinus orca	Artiodactyla	Other	Full	No	10.1016/j.cub.2021.02.057