Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
MTNR1A melatonin receptor 1A	MT1 , MEL-1A-R	Homo sapiens	3		MNTR1B		600665

Summary

This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008]

GeneOntology

Function (1)

Go ID	Value	Evidence
0004930	enables G protein-coupled receptor activity	IBA

Component (4)

Go ID	Value	Evidence
0005886	is_active_in plasma membrane	IBA
0005886	located_in plasma membrane	IDA
0005886	located_in plasma membrane	TAS
0043235	part_of receptor complex	IDA

Process (5)

Go ID	Value	Evidence
0007186	involved_in G protein-coupled receptor signaling pathway	IBA
0007187	involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS
0007193	involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA
0007623	involved_in circadian rhythm	TAS
0007617	involved_in mating behavior	TAS

Gene Loss events - MTNR1A (11 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_0K2DI7	Eschrichtius robustus	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.3390/genes10020121
GL_0ODDCE	Balaenoptera bonaerensis	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.3390/genes10020121
GL_3XZZDO	Tursiops truncatus	Artiodactyla	Gene deletion	Full	Cetacea	10.3390/genes10020121
GL_65JMHH	Lagenorhynchus obliquidens	Artiodactyla	Gene deletion	Full	Cetacea	10.3390/genes10020121
GL_BZ5P6W	Delphinapterus leucas	Artiodactyla	Gene deletion	Full	Cetacea	10.3390/genes10020121
GL_DMQFNO	Lipotes vexillifer	Artiodactyla	Gene deletion	Full	Cetacea	10.3390/genes10020121
GL_DWYRTT	Orcinus orca	Artiodactyla	Gene deletion	Full	Cetacea	10.3390/genes10020121
GL_LECURC	Physeter catodon	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.3390/genes10020121
GL_LRQMSO	Balaenoptera acutorostrata	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.3390/genes10020121
GL_PC0OGM	Trichechus manatus	Sirenia	LOF (frameshift, premature stop, ss)	Full		10.3390/genes10020121