Ψ MTNR1A - Neomonachus schauinslandi

Reference Gene:
Job_ID:
Curator:
GlossID Species Gene Loss Mechanism Loss Type Lineage Specific Evidence Accession Nr.
GL_AGIWCJ Neomonachus schauinslandi LOF (frameshift, premature stop, ss) Full No Genomic XM_021694169.1

Statements

Type Excerpt DOI
Functional "In mammals, Mtnr1a and Mtnr1b receptors are involved in the response of the clock machinery to melatonin stimulation (Reppart et al. 1996)." 10.1007/s00239-021-10025-1
Mutation Description "For Mtnr1a, a total of 44 species exhibited a PseudoIndex higher than 2 (Online Resource 3), yet manual curation revealed ORF-disrupting mutations only in pangolins (validated through SRA Projects; Online Resource 12) (Huelsmann et al. 2019), Hawaian monk seal (Neomonachus schauinslandi) and D. dugon (Online Resource 4)." 10.1007/s00239-021-10025-1
Methodology & Validation "Mutational validation was performed through retrieval of raw sequencing reads in (at least) two independent Sequence Read Archive (SRA) projects (when available)." 10.1007/s00239-021-10025-1

Curator Observations

Consult Supplementary Data 4.