Reference Gene

Gene name Alias Species Exons Type Paralogs EC number OMIM
PON1 paraoxonase 1 ESA , PON , MVCD5 Homo sapiens 9 N/A 3.1.1.2 , 3.1.1.81 , 3.1.8.1 168820

Summary

This gene encodes a member of the paraoxonase family of enzymes and exhibits lactonase and ester hydrolase activity. Following synthesis in the kidney and liver, the enzyme is secreted into the circulation, where it binds to high density lipoprotein (HDL) particles and hydrolyzes thiolactones and xenobiotics, including paraoxon, a metabolite of the insecticide parathion. Polymorphisms in this gene may be associated with coronary artery disease and diabetic retinopathy. The gene is found in a cluster of three related paraoxonase genes on chromosome 7. [provided by RefSeq, Aug 2017]

Gene Loss events - PON1 (10 results)

GL_ID Species Order Gene Loss Mechanism Loss Type Lineage Specific Citation
GL_4SWENK Enhydra lutris Carnivora LOF (frameshift, premature stop, ss) Full No 10.1126/science.aap7714
GL_5LQSLX Physeter catodon Artiodactyla LOF (frameshift, premature stop, ss) Full No 10.1126/science.aap7714
GL_77VUNQ Trichechus manatus Sirenia LOF (frameshift, premature stop, ss) Full No 10.1126/science.aap7714
GL_8OMBQV Leptonychotes weddellii Carnivora LOF (frameshift, premature stop, ss) Full No 10.1126/science.aap7714
GL_DRNKS6 Orcinus orca Artiodactyla LOF (frameshift, premature stop, ss) Full No 10.1126/science.aap7714
GL_MYNMM3 Lipotes vexillifer Artiodactyla LOF (frameshift, premature stop, ss) Full No 10.1126/science.aap7714
GL_PLA9OQ Neomonachus schauinslandi Carnivora LOF (frameshift, premature stop, ss) Full No 10.1126/science.aap7714
GL_SKKTEF Balaenoptera acutorostrata Artiodactyla LOF (frameshift, premature stop, ss) Full No 10.1126/science.aap7714
GL_SWDDUE Tursiops truncatus Artiodactyla LOF (frameshift, premature stop, ss) Full No 10.1126/science.aap7714
GL_XHHFIS Dugong dugon Sirenia LOF (frameshift, premature stop, ss) Full No 10.1126/science.aap7714