Gene Loss

Publication Details

Identifier: JB_HOG2PS

Curator: M. Lopes-Marques

DOI: 10.1007/s11427-022-2195-x

PMID: 36443512

Title:

Birth-and-death evolution of ribonuclease 9 genes in Cetartiodactyla.

Abstract:

RNase9 plays a reproductive function and has been recognized as an important member of the ribonuclease (RNase) A superfamily, a gene family that is widely used as a model for molecular evolutionary studies. Here, we identified 178 RNase9 genes from 95 Cetartiodactyla species that represent all four lineages and 21 families of this clade. Unexpectedly, RNase9 experienced an evolutionary scenario of "birth and death" in Ruminantia, and expression analyses showed that duplicated RNase9A and RNase9B genes are expressed in reproductive tissues (epididymis, vas deferens or prostate). This expression pattern combined with the estimate that these genes duplicated during the middle Eocene, a time when Ruminantia become a successful lineage, suggests that the RNase9 gene duplication might have been advantageous for promoting sperm motility and male fertility as an adaptation to climate seasonality changes of this period. In contrast, all RNase9 genes were lost in the Cetacean lineage, which might be associated with their high levels of prostatic lesions and lower reproductive rates as adaptations to a fully aquatic environment and a balance to the demands of ocean resources. This study reveals a complex and intriguing evolutionary history and functional divergence for RNase9 in Cetartiodactyla, providing new insights into the evolution of the RNaseA superfamily and molecular mechanisms for organismal adaptations to the environment.

Last update:

06-01-2025

Associated Glosses (59 results)

GlossID	Species	Symbol	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_KIO7QJ	Megaptera novaeangliae	RNASE11	Gene deletion	Full	No	10.1007/s11427-022-2195-x
GL_KNM2U0	Physeter catodon	RNASE11	Gene deletion	Full	No	10.1007/s11427-022-2195-x
GL_KZJVS1	Orcinus orca	RNASE9	Gene deletion	Full	Cetacea	10.1007/s11427-022-2195-x
GL_LAWBXF	Ziphius cavirostris	RNASE9	Gene deletion	Full	Cetacea	10.1007/s11427-022-2195-x
GL_LUIFSM	Kogia breviceps	RNASE11	Gene deletion	Full	No	10.1007/s11427-022-2195-x
GL_LUYOMV	Phocoena phocoena	RNASE11	Gene deletion	Full	No	10.1007/s11427-022-2195-x
GL_LWAMYO	Orcinus orca	RNASE11	Gene deletion	Full	No	10.1007/s11427-022-2195-x
GL_MZTE5R	Phocoena sinus	RNASE11	Gene deletion	Full	No	10.1007/s11427-022-2195-x
GL_NLDUWU	Phocoena phocoena	RNASE9	Gene deletion	Full	Cetacea	10.1007/s11427-022-2195-x
GL_NNNXNX	Tursiops truncatus	RNASE9	Gene deletion	Full	Cetacea	10.1007/s11427-022-2195-x