Gene Loss

Publication Details

Identifier: JB_GXMPRN

Curator: Nádia Silva

Title:

Parallel Independent Losses of G-Type Lysozyme Genes in Hairless Aquatic Mammals.

Abstract:

Lysozyme enzymes provide classic examples of molecular adaptation and parallel evolution, however, nearly all insights to date come from chicken-type (c-type) lysozymes. Goose-type (g-type) lysozymes occur in diverse vertebrates, with multiple independent duplications reported. Most mammals possess two g-type lysozyme genes (Lyg1 and Lyg2), the result of an early duplication, although some lineages are known to have subsequently lost one copy. Here we examine g-type lysozyme evolution across >250 mammals and reveal widespread losses of either Lyg1 or Lyg2 in several divergent taxa across the mammal tree of life. At the same time, we report strong evidence of extensive losses of both gene copies in cetaceans and sirenians, with an additional putative case of parallel loss in the tarsier. To validate these findings, we inspected published short-read data and confirmed the presence of loss of function mutations. Despite these losses, comparisons of selection pressures between intact g- and c-type lysozyme genes showed stronger purifying selection in the former, indicative of conserved function. Although the reasons for the evolutionary loss of g-type lysozymes in fully aquatic mammals are not known, we suggest that this is likely to at least partially relate to their hairlessness. Indeed, although Lyg1 does not show tissue-specific expression, recent studies have linked Lyg2 expression to anagen hair follicle development and hair loss. Such a role for g-type lysozyme would explain why the Lyg2 gene became obsolete when these taxa lost their body hair.

Last update:

01-04-2025

Associated Glosses (98 results)

GlossID	Species	Symbol	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_R2PKFF	Kogia breviceps	LYG2	LOF (frameshift, premature stop, ss)	Full	No	10.1093/gbe/evab201
GL_R55D3M	Piliocolobus tephrosceles	LYG1	Exon(s) deletion	Full	No	10.1093/gbe/evab201
GL_R5I86C	Rhinolophus ferrumequinum	LYG2	Gene deletion	Full	No	10.1093/gbe/evab201
GL_R7MW6T	Lagenorhynchus obliquidens	LYG2	LOF (frameshift, premature stop, ss)	Full	No	10.1093/gbe/evab201
GL_RD35XR	Mesoplodon bidens	LYG1	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1093/gbe/evab201
GL_RMEMXM	Carlito syrichta	LYG2	Gene deletion	Full	No	10.1093/gbe/evab201
GL_T4EZTZ	Mormoops blainvillei	LYG2	Gene deletion	Full	No	10.1093/gbe/evab201
GL_TEEJXS	Sus scrofa	LYG1	Exon(s) deletion	Full	No	10.1093/gbe/evab201
GL_THDCCT	Vicugna pacos	LYG1	Exon(s) deletion	Full	No	10.1093/gbe/evab201
GL_TUYEQU	Platanista minor	LYG2	LOF (frameshift, premature stop, ss)	Full	No	10.1093/gbe/evab201