Ψ KRT6B - Ovis aries

Reference Gene:
Job_ID:
Curator:
GlossID Species Gene Loss Mechanism Loss Type Lineage Specific Evidence Accession Nr.
GL_XVRKFN Ovis aries Other Full No Genomic & Synteny maps

Statements

Type Excerpt DOI
Functional "Previous study has reported that deficient for K6B (epithelial keratins) may contributed to the absence of hair and nail in mice." 10.1186/s12983-017-0225-x
Methodology & Validation "We first identified α-keratin gene repertoires in the cow (Bos taurus) (coverage 7×,Btau_4.6.1) [...] taking all the known α-keratin gene sequences of human as queries using BLASTN and TBLASTN algorithm. [...] [Using the putative α-keratin cow genes as query,] the orthologous α-keratin genes were also scanned from the genome of [marine mammals'] terrestrial relatives, such as sheep (Ovis aries, coverage 142×, Oar_v3.1, NCBI)." 10.1186/s12983-017-0225-x
Other "However, some genes within one specie grouped together rather than with the members of the same family in other species, such as among the genes of K31, K33A, K33B and K34 in type I, as well as the K6A, K6B, K6C, K81, K83, K87 and K86 in the type II." 10.1186/s12983-017-0225-x

Curator Observations

The authors named the keratins according to the human nomenclature. The authors describe this as a "pseudogene", and no further explanation or sequence information is provided. As such, the gene loss mechanism is inconclusive.