Ψ GSDMD - Manis pentadactyla
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_X7ZYW9 | Manis pentadactyla | Exon(s) deletion | Full | Yes | Genomic | XM_057497704.1 |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Phenotypic | "In addition to skin build-up and maintenance, gasdermins, notably Gsdmb and Gsdmd, were shown to affect T-cell differentiation and function, as well as macrophage infiltration, protecting the skin against bacterial infections and contributing to the pathophysiology of skin diseases, such as psoriasis or skin fibrosis (Liu et al. 2021; Yang et al 2022; Ji et al 2023)." | 10.1007/s00239-023-10118-z |
Curator Observations
Exon 6 was either not found or displayed low identity in all examined species.