Ψ TAS2R5 - Sousa chinensis

Reference Gene:
Job_ID:
Curator:
GlossID Species Gene Loss Mechanism Loss Type Lineage Specific Evidence Accession Nr.
GL_X4QM3U Sousa chinensis LOF (frameshift, premature stop, ss) Full Yes PCR & Sanger Sequencing Single

Statements

Type Excerpt DOI
Mutation Description "Based on sequence alignments against cow (Bos taurus) homologues, we identified multiple ORF-disrupting indels and premature stop codons in Tas1r1, Tas1r2, Pkd2l1 and in ten Tas2rs scattered among cetacean branches." 10.1186/s12862-014-0218-8
Timing of Loss "In Tas2r2, Tas2r5 and Tas2r16, we found shared ORF-disrupting mutations and/or premature stop codons in all toothed whales, such as a 1 bp or a 2 bp deletion in Tas2r2 (Additional file 3: Figure S5), a shared TGA premature stop codon in Tas2r5 (Additional file 3: Figure S7), and a 4 bp deletion in Tas2r16 (Additional file 3: Figure S8), suggesting that the functional loss of these genes happened in the common ancestor of toothed whales." 10.1186/s12862-014-0218-8
Other "SEE "Additional file 3: Figures S1-S11. Indels and premature stop codons in Pkdl21, Tas1r1, Tas1r2, Tas2r1-3, Tas2r5, Tas2r16, Tas2r38-39, and Tas2r60." 10.1186/s12862-014-0218-8

Curator Observations

Isolated sequences have been deposited by authors in GenBank [GenBank: KJ524713-KJ524837]. Conserved LOF mutation suggest that gene loss occurred in the ancestral of Odontoceti species.