| Functional |
"MAP3K19 is expressed in bronchial epithelial cells, type II pneumocytes, and pulmonary macrophages (42). Overexpression of MAP3K19 was detected in pulmonary macrophages of human patients suffering from idiopathic pulmonary fibrosis (42)." |
10.1126/sciadv.aaw6671 |
| Mutation Description |
"Our screen revealed two genes that are exclusively lost in cetaceans and have specific expression patterns in the lung, MAP3K19 and SEC14L3 (Fig. 3, A and B, and figs. S7 and S8)." |
10.1126/sciadv.aaw6671 |
| Phenotypic |
"MAP3K19 is expressed in bronchial epithelial cells, type II pneumocytes, and pulmonary macrophages (42). Overexpression of MAP3K19 was detected in pulmonary macrophages of human patients suffering from idiopathic pulmonary fibrosis (42). In a similar manner, MAP3K19 loss may also have a protective effect in cetaceans where repeated lung collapse/reinflation events during deep dives cause shear forces that could increase the incidence of pulmonary microinjuries." |
10.1126/sciadv.aaw6671 |