Ψ PCSK9 - Elaphurus davidianus
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_VGOE2E | Elaphurus davidianus | Exon(s) deletion | Full | Yes | Genomic |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Mutation Description | "On the contrary, Pecora had the remnants of a PCSK9 pseudogene, including exons 8, 9, 10, 12 and parts of exons 7 and 11. Interestingly, two major structural alterations affecting 38 of the 39 species analysed could be reconstituted: a large deletion extending from the BSND-PCSK9 intergenic region to exon 7, and a smaller deletion from exon 11 to intron 11." | 10.1007/s10709-021-00113-x |
| Timing of Loss | "The loss of PCSK9 in Cetartiodactyla can thus be inferred to have taken place in the time interval from the Whippomorpha-Ruminantia split (ca. 70 My bp) to the divergence of Ruminantia (ca. 52 My bp) (Hassanin et al. 2012)." | 10.1007/s10709-021-00113-x |
Curator Observations
Authors identified a shared large deletion in all Ruminantia analyzed.