Ψ LYG2 - Megaptera novaeangliae

Reference Gene:
Job_ID:
Curator:
GlossID Species Gene Loss Mechanism Loss Type Lineage Specific Evidence Accession Nr.
GL_V337F5 Megaptera novaeangliae Gene deletion Undetermined No Genomic

Statements

Type Excerpt DOI
Functional "Some insights into the possible roles of Lyg1 and Lyg2 come from expression data. The former gene does not appear to show strong tissue-specific expression patterns, with expression reported across several organs and a peak in the kidney (Liu et al. 2017). In contrast, Lyg2 is highly expressed in specific tissues, notably the skin (Irwin 2014), eyes, and testes (Huang et al. 2011). Given that the encoded gene product of Lyg2 is predicted to retain antibacterial activity (Irwin 2014)—and thus might play a role in immunity (Huang et al. 2011)—it is plausible that expression in the skin might serve as the first line of defense. If so, then the fact that whale skin has been reported to regenerate much faster than human skin might lead to a reduced necessity for antimicrobial activity in these species (Hicks et al. 1985)." 10.1093/gbe/evab201
Mutation Description "Uncertain. Missing/incomplete exons with possible sequencing or assembly problems." 10.1093/gbe/evab201
Methodology & Validation "Putative pseudogene sequences were confirmed by searching the raw sequence data in the SRA database. SRA database." 10.1093/gbe/evab201

Curator Observations

This species has also lost Lyg1 gene. Although the authors mention SRA validation of the identified mutations, this is not shown in the manuscript and supplemental data.