Ψ PCSK9 - Ochotona princeps

Reference Gene:
Job_ID:
Curator:
GlossID Species Gene Loss Mechanism Loss Type Lineage Specific Evidence Accession Nr.
GL_TTLOD7 Ochotona princeps Exon(s) deletion Full No Genomic XM_058680820.1

Statements

Type Excerpt DOI
Mutation Description "PCSK9 has clearly undergone pseudogenization in this species, as several exons were lost, and the remaining had three nonsense mutations, all of which were confirmed by raw sequence data." 10.1007/s10709-021-00113-x
Timing of Loss "At present, and in the absence of additional data, it is not possible to determine whether the inactivation is common to the entire family Ochotonidae, or a restricted phenomenon." 10.1007/s10709-021-00113-x
Other "All species of Dermoptera, Scandentia and Lagomorpha had apparently normal PCSK9 genes, except for the American pika (Ochotona princeps)." 10.1007/s10709-021-00113-x

Related Glosses

GL_ID Symbol Species Order Gene Loss Mechanism Loss Type Lineage Specific Citation
GL_NONKDG PCSK9 Ochotona princeps Lagomorpha LOF (frameshift, premature stop, ss) Full No 10.1093/nargab/lqz012