| Timing of Loss |
"The phyletic distribution of the functional and non-functional copies of RLN1 indicates that the common ancestor of cetaceans and ruminants had a functional copy of the RLN1 gene, which was lost between the split of the giraffe and bovid lineages, dated to ~29 million years ago, and the split between artiodactyls andcetaceans, dated to ~56 million years ago." |
10.1016/j.ygcen.2017.07.011 |
| Phenotypic |
"In fact, cow and sheep posses putatively functional copies of the 4 RXFP receptors described for mammals (Supplementary Table 2). Thus, we suspect the relaxin signaling pathway remains functional, which explains why cattle respond to pig relaxin, even though they cannot actually produce it (Bagna et al., 1991)" |
10.1016/j.ygcen.2017.07.011 |
| Other |
"The RLN1 pseudogene includes two well-defined exons in sheep, goat and giraffe, but has been altogether lost in cow" |
10.1016/j.ygcen.2017.07.011 |