Ψ KRT79 - Physeter catodon
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_TLPJ4C | Physeter catodon | Other | Full | No | Genomic & Synteny maps | XM_024122965.3 |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Methodology & Validation | "We first identified α-keratin gene repertoires in the cow (Bos taurus) (coverage 7×,Btau_4.6.1) [...] taking all the known α-keratin gene sequences of human as queries using BLASTN and TBLASTN algorithm. [...] The putative α-keratin genes in the cow were then taken as queries to explore the α-keratin multigene family in the genome of 11 marine mammals, including [...] sperm whale (Physeter macrocephalus, coverage 75×, Physeter_macrocephalus_2.0.2, NCBI)." | 10.1186/s12983-017-0225-x |
| Phenotypic | "Our results show an apparent reduction in the α-keratin gene repertoire and increased rate of pseudogenization in cetaceans when compared to terrestrial counterparts, which may be associated with their hairless phenotype." | 10.1186/s12983-017-0225-x |
Curator Observations
The authors named the keratins according to the human nomenclature. The authors describe this as a "pseudogene", and no further explanation or sequence information is provided. As such, the gene loss mechanism is inconclusive. This gene loss is likely to be Cetacea-specific according to the papers' data; however, as the authors don't provide sequence information.