Ψ MLKL - Lagenorhynchus obliquidens
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_RWSTD4 | Lagenorhynchus obliquidens | LOF (frameshift, premature stop, ss) | Full | Yes | Genomic | XM_027119916.1 |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Mutation Description | "Interestingly, while Cetacean RIPK3 inactivation appears to be a result of different mutations depending on the studied species, our results show a shared mutation in the exon 1 of MLKL in all cetacean species (Figure 3B). Moreover, this premature stop codon leads to the absence of exon 2, 3, 4 and 5 in most cetacean species, which very likely results in this gene inactivation." | 10.3389/fimmu.2021.747737 |
| Timing of Loss | "Given the presence of an inactivating mutation that is shared between mysticetes and odontocetes, the most parsimonious hypothesis suggests that they occurred before the split of these two clades in the common ancestral branch of Cetacea." | 10.3389/fimmu.2021.747737 |