Ψ Cym - Leptonychotes weddellii

Reference Gene:
Job_ID:
Curator:
GlossID Species Gene Loss Mechanism Loss Type Lineage Specific Evidence Accession Nr.
GL_RPQ4NL Leptonychotes weddellii LOF (frameshift, premature stop, ss) Undetermined No Multiple individual SRA XM_006749503.2

Statements

Type Excerpt DOI
Mutation Description "Gene annotation revealed a 2 bp frameshift in exon 9 in Leptonychotes weddellii and 5 bp frameshift in exon 7 in Ursus maritimus. However, the validation of these mutations by SRA search displayed dissimilarities between the source genomic sequences in NCBI and the SRA read archives. In the case of Leptonychotes weddellii, we found 10 reads from 2 independent SRA runs SRA353375 and SRA353374 confirming a 2 bp insertion, however 3 reads from SRR332059 did not validate this insertion. (...) Thus, the Cmy sequences for Ursus maritimus, Leptonychotes weddellii and Ornithorhynchus anatinus were regarded as most probably coding." 10.1016/j.ympev.2017.08.014
Other "Thus, the Cmy sequences for Ursus maritimus, Leptonychotes weddellii and Ornithorhynchus anatinus were regarded as most probably coding." 10.1016/j.ympev.2017.08.014

Curator Observations

SRA evidence supports a polymorphic pseudogenes status, in addition the location of the mutation in the last exon of the gene makes the coding status of this gene in this species dubious.