| Functional |
"Comparative genomics showed that NLRP10, PYDC1, and CASP14, which are transcriptionally upregulated during human keratinocyte differentiation, lack functional orthologs in cetaceans (Fig. 3B; Suppl. Fig. S12)» (Lachner et al., 2017, p. 6)." |
10.1038/s41598-017-17782-4 |
| Methodology & Validation |
"The genome sequences (…) were investigated for the presence and sequence integrity of genes related to pyroptosis and IL-1 signaling." |
10.1038/s41598-017-17782-4 |
| Timing of Loss |
"Our comparative genomics data indicate that NLRP10 as well as NLRP1 have been lost in a common ancestor of cetaceans and cattle, indicating that its function was dispensable or even disadvantageous. As this ancestor had a terrestrial lifestyle, loss of NLRP10 was likely not associated with a change in the epidermal differentiation program but perhaps with the regulation of immune responses to pathogens." |
10.1038/s41598-017-17782-4 |
| Other |
"Screening gene expression levels in human tissues suggested that NLRP10, PYDC1, and CASP14 are predominantly expressed in epidermal keratinocytes (Suppl. Fig. S10)." |
10.1038/s41598-017-17782-4 |