| Mutation Description |
"In Caniformia, traces of gradual gene degradation over evolutionary time could still be found when comparing the basal Canidae to more recent families (Fig. 4). Indeed, while Canidae typically lack only exons 3 and 5, two additional deletions caused the loss of exons 4, 7 to 9 and part of exon 10 after the UrsidaeCanidae split, as evidenced by the sequences of Ursidae, Pinnipedia and Ailuridae." |
10.1007/s10709-021-00113-x |
| Mutation Description |
"In Feliformia, on the other hand, only exon 12 has been preserved in Felidae and Hyaenidae, while Viverridae also contained a fragment of exon 6, and Herpestidae and Eupleridae have retained exons 10 to 12 (ST2)." |
10.1007/s10709-021-00113-x |
| Timing of Loss |
"In Carnivora, none of the 63 species analysed had a functional gene, but there was a marked difference in the pattern of gene inactivation between the suborders Caniformia and Feliformia." |
10.1007/s10709-021-00113-x |
| Timing of Loss |
"Interestingly, all extant exon 12 sequences from Feliformia and Canidae (although not from other Caniformia) seemed to share a 5-bp insertion (Fig. 4), suggesting that PCSK9 inactivation took place before the Caniformia-Feliformia split and therefore very early in the evolution of Carnivora." |
10.1007/s10709-021-00113-x |