Ψ MOGAT3 - Physeter catodon

Reference Gene:
Job_ID:
Curator:
GlossID Species Gene Loss Mechanism Loss Type Lineage Specific Evidence Accession Nr.
GL_PI09XF Physeter catodon LOF (frameshift, premature stop, ss) Full Yes Multiple individual SRA

Statements

Type Excerpt DOI
Functional "Thus, two scenarios could be put forward regarding the inactivation of Mogat3. First, it could reflect convergent skin-specific molecular changes, more specifically degeneration of SGs or changes in sebum lipid composition(Nikkari 1974)." 10.1093/molbev/msz068
Functional "Alternatively, Mogat3 loss could be related to dietary adaptations, especially to herbivory, as in the case of T. m. latirostris, C. s. simum and L. africana." 10.1093/molbev/msz068
Mutation Description "We identified several ORF disrupting mutations in both Dgat2l6 and Mogat3 in all of the analyzed Cetacea. Regarding Dgat2l6, a single mutation, namely a one nucleotide deletion in exon 3, was found to be conserved across all tested species, whereas in Mogat3 several conserved mutations were identified, such as a five nucleotide insertion in exon 2, a loss of canonical 30splice site in exon 3 (GT>GC) and the presence of a stop codon in exon 6 (fig. 2A)." 10.1093/molbev/msz068

Related Glosses

GL_ID Symbol Species Order Gene Loss Mechanism Loss Type Lineage Specific Citation
GL_664GMZ MOGAT3 Physeter catodon Artiodactyla LOF (frameshift, premature stop, ss) Full Cetacea 10.1016/j.cub.2021.02.057