Ψ GRK7 - Ziphius cavirostris

Reference Gene:
Job_ID:
Curator:
GlossID Species Gene Loss Mechanism Loss Type Lineage Specific Evidence Accession Nr.
GL_OAJZOT Ziphius cavirostris LOF (frameshift, premature stop, ss) Full No Genomic

Statements

Type Excerpt DOI
Functional "The protein product of GRK7 phosphorylates cone opsins in many mammalian species, and there is evidence of species-specific expression differences of GRK7 in cones (Liu et al. 2005)." 10.1093/molbev/msaa070
Mutation Description "Putative GRK7 and GUCY2F pseudogenes are found within species of Ziphiidae, Kogiidae, Mysticeti, and Pontoporiidae (table 1)." 10.1093/molbev/msaa070
Phenotypic "The loss of function in GRK7 and other cone-specific genes identified here (OPN1LW, CNGB3, CNGA3, GNAT2, PDE6C) indicates that many more cetacean species have lost cone-mediated vision..." 10.1093/molbev/msaa070
Other "Other mammals, many of which are active in dim-light environments, such as mice and subterranean rodents, goldenmoles, xenarthrans, some bats, and tenrecs, also have lost GRK7 (Weiss et al. 2001; Emerling and Springer 2014, 2015; Fang et al. 2014; Hudson et al. 2014; Emerling 2018)." 10.1093/molbev/msaa070

Curator Observations

Authors used Illumina genomic libraries and coverage to investigate coding status of the target genes (See table 1). Authors identified a 5nt insertion in exon 7.