| Mutation Description |
"These comparisons revealed the presence of multiple premature stop codons in goat, giraffe, sheep and Tibetan antelope; our results suggest that, in addition to coding sequence mutations, changes in the 50 regulatory sequence in the common ancestor of giraffe and bovids were probably also involved in the loss of a functional RLN1 gene in this group." |
10.1016/j.ygcen.2017.07.011 |
| Timing of Loss |
"The phyletic distribution of the functional and non-functional copies of RLN1 indicates that the common ancestor of cetaceans and ruminants had a functional copy of the RLN1 gene, which was lost between the split of the giraffe and bovid lineages, dated to ~29 million years ago, and the split between artiodactyls andcetaceans, dated to ~56 million years ago." |
10.1016/j.ygcen.2017.07.011 |
| Other |
"The current assembly of the Tibetan antelope genome appears to represent an intermediate state, with a well-defined exon 2 and an exon 1 which has greatly diverged." |
10.1016/j.ygcen.2017.07.011 |