Ψ PCSK9 - Zapus hudsonius

Reference Gene:
Job_ID:
Curator:
GlossID Species Gene Loss Mechanism Loss Type Lineage Specific Evidence Accession Nr.
GL_NGXZIJ Zapus hudsonius Exon(s) deletion Full No Genomic

Statements

Type Excerpt DOI
Mutation Description "As for the meadow jumping mouse, the species apparently lost exons 1, 2, 4 and 5, had four frame-shifting indels and an independent nonsense mutation in codon 419, as well as missense mutations affecting N317, S386, C562, C588 and C601 (SF8).None of the apparent defects could be confirmed by raw sequence data analysis as these are unavailable, but nevertheless it seems highly likely that PCSK9 has also become a pseudogene in the jumping mouse." 10.1007/s10709-021-00113-x
Timing of Loss "Taken together, these results suggest that PCSK9 was independently inactivated in the Egyptian jerboa and the jumping mouse, but the possibility remains that inactivation took place in a common ancestor—and, in the latter case, the question at which point in dipodid phylogeny it occurred remains open." 10.1007/s10709-021-00113-x