Ψ UCP1 - Manis pentadactyla
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_MUR7OM | Manis pentadactyla | LOF (frameshift, premature stop, ss) | Full | No | Genomic | XM_057503275.1 |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Functional | "Adaptive nonshivering thermogenesis (NST) of placental mammals is predominantly mediated by uncoupling protein 1 (UCP1), which resides at high levels in the mitochondrial inner membrane of brown adipose tissue (BAT) (1)." | 10.1126/sciadv.1602878 |
| Timing of Loss | "The earliest disruptions of ucp1 function (likely Cretaceous; Fig. 3 and table S3) occur in the ancestors of xenarthrans and pangolins, two groups that exhibit marked convergence in many ecological, morphological, and physiological traits and which are generally characterized by mediocre temperature-regulating mechanisms and low, labile body temperatures (29–32)." | 10.1126/sciadv.1602878 |
Curator Observations
Several disruptive mutations including bp deletion and in-frame permature stop codons