Ψ FLG2 - Dugong dugon
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_MMINO5 | Dugong dugon | LOF (frameshift, premature stop, ss) | Undetermined | No | Genomic |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Mutation Description | "However, due to premature stop codons the proteins encoded by FLG, FLG2 and TCHHL1 are more than 50% shorter in sirenians than in elephants and humans (Fig. 5A, Supplementary Fig. S7)." | 10.1038/s41598-024-60099-2 |
| Mutation Description | "Both species of sirenians lack the C-terminal motif in the predicted FLG2 and TCHHL1 proteins (Fig. 5B)." | 10.1038/s41598-024-60099-2 |
| Mutation Description | "FLG2 of the dugong is predicted to be extremely short because of an in-frame stop codon in the currently available genome sequence. The sequence downstream of this predicted stop codon does not contain further stops for more than 2000 codons, suggesting that this gene has acquired the premature stop only recently in evolution." | 10.1038/s41598-024-60099-2 |
Curator Observations
Authors indicate that the protein has suffered a large truncation, due to a premature stop codon in the gene, but do not discard a functionality.