Ψ UCP1 - Delphinapterus leucas
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_LSDIYO | Delphinapterus leucas | LOF (frameshift, premature stop, ss) | Full | Yes | Genomic |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Functional | "Adaptive nonshivering thermogenesis (NST) of placental mammals is predominantly mediated by uncoupling protein 1 (UCP1), which resides at high levels in the mitochondrial inner membrane of brown adipose tissue (BAT) (1)." | 10.1126/sciadv.1602878 |
| Timing of Loss | "Notably, the non-delphinid cetacean UCP1 primary sequences presented in the latter study show premature stop codons stemming from both nonsense and frameshift mutations (as also seen in Fig. 1), whereas the presented killer whale and bottlenose dolphin “UCP1 sequences correspond to UCP2 and UCP3, respectively. Our results further indicate that the pseudogenization of ucp1 also immediately predates strong increases in body size during the early amphibious stages of archaeocete evolution [that is, from 15- to 30-kg Himalayacetus (52.5 Ma) to 590- to 720-kg Ambulocetus/Rodhocetus (48 Ma) (50, 51)]" | 10.1126/sciadv.1602878 |
Curator Observations
A conserved loss of 4bp was found in all cetacean's sepcies that did not loss the exon
Related Glosses
| GL_ID | Symbol | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|---|
| GL_JWA2GY | UCP1 | Delphinapterus leucas | Artiodactyla | Gene deletion | Full | No | 10.1073/pnas.2106080118 |