| Mutation Description |
"For Trichechus manatus (West Indian manatee) and Orycteropus afer (aardvark), we recovered incomplete MC5R sequences that result from similar but not identical deletions in these gene sequences." |
10.1016/j.ympev.2017.12.010 |
| Mutation Description |
"In T. manatus there is a 2823 bp deletion (relative to Loxodonta africana [African elephant]) that spans 1991 bp of sequence that is 5' to the coding region of MC5R plus 832 bp of MC5R coding sequence (Fig. 3). The residual protein-coding sequence at the 3' end of MC5R in T. manatus is 129 bp long, including the stop codon, on contig 141950 (nucleotide positions 11177-11305 of AHIN01141950)." |
10.1016/j.ympev.2017.12.010 |
| Phenotypic |
"Here, we show that MC5R has either been deleted from the genome or inactivated in multiple mammalian lineages that have lost their sebaceous glands or have degenerative sebaceous glands
including fully aquatic cetaceans and West Indian manatee, pangolins, African elephant, and white rhinoceros." |
10.1016/j.ympev.2017.12.010 |