| Mutation Description |
"In Pholidota, which includes only one family comprised of eight species (Gaubert and Antunes 2005), PCSK9 was inactivated in the two species for which there was available data (the Sunda pangolin, Manis javanis, and the Chinese pangolin, Manis pentadactyla). The inactivation of the gene occurred before the two species diverged, as attested by similar alterations in gene structure (losses of exons 1 and exons 4 to 10, and inversion affecting exons 2 and 3) and sequence (e.g. three frameshift mutations in exon 2) (ST2, Fig. 5). This similarity is not surprising, as the two species are closely related (Gaudin et al. 2009), but it should be noted that the sequences also provided evidence of additional recent gene degradation, as only the Chinese pangolin has lost exon 12 (Fig. 5)." |
10.1007/s10709-021-00113-x |