Ψ UCP1 - Mammuthus primigenius

Reference Gene:
Job_ID:
Curator:
GlossID Species Gene Loss Mechanism Loss Type Lineage Specific Evidence Accession Nr.
GL_JFNDC0 Mammuthus primigenius LOF (frameshift, premature stop, ss) Full Yes Genomic

Statements

Type Excerpt DOI
Functional "Adaptive nonshivering thermogenesis (NST) of placental mammals is predominantly mediated by uncoupling protein 1 (UCP1), which resides at high levels in the mitochondrial inner membrane of brown adipose tissue (BAT) (1)." 10.1126/sciadv.1602878
Timing of Loss "For example, theearliest proboscideans [59 to 60 million–year–old (Ma) Eritherium(41)] and hyraxes [~55-Ma Seggeurius (42)] were small (~3 to 5 kg)but gave rise to much larger species (for example, 3600-kg Barytheriumand 800- to 1400-kg Titanohyrax ulitimus), coincident with our esti-mates of ucp1 inactivation. Although large-bodied (~625- to 800-kg)hyracoids such as “Titanohyrax” mongereaui are also known from ear-lier deposits, the presence of only a single, “primitive” Seggeurius-sizedspecies (Dimaitherium patnaiki) from the early Priabonian (~37 Ma)suggests that gigantism evolved independently in Middle and Late Eo-cene hyracoids (43). " 10.1126/sciadv.1602878

Curator Observations

A conserved deletion of 1bp was observed in all elephant species